Back to search

Article

Development of a Staining-based Electrophoretic Mobility Shift Assay for Analyzing Pbx1, DNA and HoxA9 Interactions

2026-06-07

Abstract excerpt

Transcription factors (TFs) are master regulators of gene expression and control a wide range of cellular functions including embryonic development, signaling pathways, immune response, and differentiation. A tight regulation of gene expression is crucial during all stages of life and changes in the TF function can lead to developmental abnormalities, diseases such as cancer, or resistance to treatment. Therefore,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
28998c0a-97a0-53bc-8a10-8de0b333fe99
DOI
10.64898/2026.06.03.729869
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Development of a Staining-based Electrophoretic Mobility Shift Assay for Analyzing Pbx1, DNA and HoxA9 InteractionsDOI 10.64898/2026.06.03.729869
Quantitative high-throughput analysis of transcription factor binding specificities.Semantic proximity
Sequence-specific recognition of DNA by hydrophobic, alanine-rich mutants of the basic region/leucine zipper motif investigated by fluorescence anisotropy.Semantic proximity
Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context.Semantic proximity
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.Semantic proximity
Allele-specific DNA-protein interactions associated with the X-box regulatory region of the DQB1*0302 gene.Semantic proximity
Regulation of BCL11A DNA binding and expression in human erythrocyte precursor HUDEP-2 cellsSemantic proximity
Induction of AML cell differentiation using HOXA9/DNA binding inhibitors as a potential therapeutic option for HOXA9‐dependent AMLSemantic proximity
Role of MNX1-mediated Histone Modifications and PBX Gene Family in MNX1-induced LeukemogenesisSemantic proximity
Select a neighboring publication to make it the new centre.