Regulatory mechanism of human factor IX gene: protein binding at the Leyden-specific region.

doi:10.1021/bi00172a039

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Article

Regulatory mechanism of human factor IX gene: protein binding at the Leyden-specific region.

Biochemistry - 15 Feb 1994

Kurachi S, Furukawa M, Salier J P, Wu C T, Wilson E J, French F S, Kurachi K

Abstract excerpt

Hemophilia B-Leyden is characterized by the gradual amelioration of bleeding after the onset of puberty. All Leyden phenotype mutations found to date lie within the Leyden-specific region, which spans roughly nt-40 to +20 in the 5' end of the human factor IX gene. With HepG2 cell nuclear extracts...

Topics

Animals
Base Sequence
Binding Sites
Cell Line
Chlorocebus aethiops
Cricetinae
DNA
DNA-Binding Proteins
Deoxyribonuclease I
Factor IX
Humans
Male
Molecular Sequence Data
Mutation
Rats
Rats, Sprague-Dawley
Receptors, Androgen
Regulatory Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8312279
DOI: 10.1021/bi00172a039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8312279-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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