Article
Different binding of NF-Y transcriptional factor to DQA1 promoter variants.
Human immunology - 1 Dec 1998
Indovina P, Megiorni F, Ferrante P, Apollonio I, Petronzelli F, Mazzilli M C
Abstract excerpt
Polymorphism in the HLA-DQA1 promoter (QAP) sequences could influence the gene expression through a differential binding of transcriptional factors. Considering the main role played by the Y-box in the transcription, we focused on the QAP4 variants differing for a G vs A transition from the QAP Y...
Topics
- Base Sequence
- Blotting, Northern
- CCAAT-Enhancer-Binding Proteins
- Cell Line, Transformed
- DNA-Binding Proteins
- Genes, MHC Class II
- Genetic Variation
- HLA-DQ Antigens
- Humans
- Molecular Sequence Data
- Promoter Regions, Genetic
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Alignment
- Transcription Factors