Article
Human endothelial cell-derived nuclear proteins that recognise polymorphic DNA elements in the von Willebrand factor gene promoter include YY1.
Thrombosis and haemostasis - 1 Aug 2001
Costa M, Grant P J, Rice G I, Futers T S, Medcalf R L
Abstract excerpt
Four common base-change polymorphisms have been found in the von Willebrand factor gene promoter: (-1793 C/G, -1234 T/C, -1185 G/A and -1051 A/G). All four polymorphisms are in strong linkage disequilibrium and recent reports have indicated these polymorphisms are associated with plasma vWF:Ag levels suggesting that one or more of these elements influence regulation of the vWF gene. We report that human...
Topics
- Base Sequence
- Binding Sites
- Binding, Competitive
- DNA-Binding Proteins
- Electrophoretic Mobility Shift Assay
- Endothelium, Vascular
- Erythroid-Specific DNA-Binding Factors
- Gene Frequency
- Humans
- Nuclear Proteins
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic