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Article

Regulatory factor-X binding to mutant HLA-DRA promoter sequences.

Nucleic acids research - 25 Mar 1991

Hasegawa S L, Sloan J H, Reith W, Mach B, Boss J M

Abstract excerpt

The class II genes of the major histocompatibility complex (MHC) encode a family of cell surface glycoproteins that present processed antigen to the T cell receptor. Class II genes are regulated coordinately, responding to both immunologic and developmental signals. Conserved sequence elements 5' to class II genes have been shown to be important in transcriptional control. One of these sequences, the X box, is a...

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Identifiers

PMID: 1903200
DOI: 10.1093/nar/19.6.1243
PMCID: PMC333849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulatory factor-X binding to mutant HLA-DRA promoter sequences.PMID 1903200Read ↗

Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.Semantic proximity Read ↗

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RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.Semantic proximity Read ↗

Class II MHC transcriptional mutants are defective in higher order complex formation.Semantic proximity Read ↗

Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.Semantic proximity Read ↗

The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.Semantic proximity Read ↗

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.Semantic proximity Read ↗

A patient with RFX5 variant causing an expression defect in both HLA ABC and HLA DR.Semantic proximity Read ↗

The X1 box of HLA-G promoter is a target site for RFX and Sp1 factors.Semantic proximity Read ↗

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

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