Article
DEK binding to class II MHC Y-box sequences is gene- and allele-specific.
Arthritis research & therapy - 1 Jan 2003
Adams Barbara S, Cha Hyuk C, Cleary Joanne, Haiying Tan, Wang Hongling, Sitwala Kajal, Markovitz David M
Abstract excerpt
Using electrophoretic mobility shift assays, we examined sequence-specific binding of DEK, a potential autoantigen in juvenile rheumatoid arthritis, to conserved Y-box regulatory sequences in class II MHC gene promoters. Nuclear extracts from several cell lines of different phenotypes contained sequence-specific binding activity recognizing DRA, DQA1*0101, and DQA1*0501 Y-box sequences. Participation of both DEK...
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