Article
Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.
The Journal of biological chemistry - 10 Jun 1994
Chen J, Ishii M, Wang L, Ishii K, Coughlin S R
Abstract excerpt
Cleavage of the thrombin receptor's amino-terminal exodomain at the Arg41/Ser42 peptide bond within the sequence ... LDPR41/S42FLLRN ... is necessary and sufficient for receptor activation by proteases. The synthetic peptide SFLLRN activates the receptor independent of proteolysis. We proposed th...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Cells, Cultured
- Ligands
- Models, Biological
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phenotype
- Receptors, Thrombin
- Recombinant Fusion Proteins
- Signal Transduction
- Thrombin
- Xenopus