Article
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry - 22 Mar 1994
Mathews I I, Padmanabhan K P, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck C W, Coughlin S R, Fenton J W
Abstract excerpt
Many of the vital actions of thrombin on platelets and other cells appear to be mediated by the recently cloned seven-transmembrane-domain thrombin receptor. Thrombin activates this receptor by a novel proteolytic mechanism. The amino-terminal exodomain of the receptor contains the sequence LDPRSFLLRNPNDKYEPF. Structure-activity studies with mutant receptors and receptor peptides suggest that this sequence binds...
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