Article
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Biochemistry - 22 Mar 1994
Mathews I I, Padmanabhan K P, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck C W, Coughlin S R, Fenton J W
Abstract excerpt
Many of the vital actions of thrombin on platelets and other cells appear to be mediated by the recently cloned seven-transmembrane-domain thrombin receptor. Thrombin activates this receptor by a novel proteolytic mechanism. The amino-terminal exodomain of the receptor contains the sequence LDPRS...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallization
- Crystallography, X-Ray
- Hydrogen Bonding
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Peptide Fragments
- Protein Binding
- Protein Conformation