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Article

Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling.

The Journal of biological chemistry - 12 Jan 1996

Nanevicz T, Wang L, Chen M, Ishii M, Coughlin S R

Abstract excerpt

Constitutively active thrombin receptors were generated while constructing chimeric receptors to identify the structural basis for thrombin receptor agonist specificity. Substitution of eight amino acids from the Xenopus receptor's second extracellular loop (XECL2B) for the cognate sequence in the human thrombin receptor was sufficient to confer robust constitutive activity. Smaller substitutions within the...

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Identifiers

PMID: 8557676
DOI: 10.1074/jbc.271.2.702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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