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Article

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

The Journal of biological chemistry - 25 Jun 2010

Larsen Katrine S, Ostergaard Henrik, Olsen Ole H, Bjelke Jais R, Ruf Wolfram, Petersen Lars C

Abstract excerpt

The complex of factor VIIa (FVIIa) with tissue factor (TF) triggers coagulation by recognizing its macromolecular substrate factors IX (FIX) and X (FX) predominantly through extended exosite interactions. In addition, TF mediates unique cell-signaling properties in cancer, angiogenesis, and infla...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20388709
DOI: 10.1074/jbc.M110.101030
PMCID: PMC2888407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20388709-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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