Article
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
The Journal of clinical investigation - 1 Feb 1992
Hung D T, Vu T K, Wheaton V I, Charo I F, Nelken N A, Esmon N, Esmon C T, Coughlin S R
Abstract excerpt
Platelet activation by thrombin plays a critical role in hemostasis and thrombosis. Based on structure-activity studies of a cloned platelet thrombin receptor, we designed two "mirror image" antagonists of thrombin and thrombin receptor function. First, "uncleavable" peptides mimicking the recept...
Topics
- Amino Acid Sequence
- Binding Sites
- Fibrinolytic Agents
- Humans
- Molecular Sequence Data
- Mutation
- Platelet Activation
- Receptors, Cell Surface
- Receptors, Thrombin
- Recombinant Proteins
- Structure-Activity Relationship
- Thrombin