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Article

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

The Journal of clinical investigation - 1 Feb 1992

Hung D T, Vu T K, Wheaton V I, Charo I F, Nelken N A, Esmon N, Esmon C T, Coughlin S R

Abstract excerpt

Platelet activation by thrombin plays a critical role in hemostasis and thrombosis. Based on structure-activity studies of a cloned platelet thrombin receptor, we designed two "mirror image" antagonists of thrombin and thrombin receptor function. First, "uncleavable" peptides mimicking the receptor domain postulated to interact with thrombin were found to be potent thrombin inhibitors. Second, proteolytically...

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Identifiers

PMID: 1310695
DOI: 10.1172/JCI115604
PMCID: PMC442871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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