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Article

Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer.

The Journal of biological chemistry - 22 Jun 2018

Maun Henry R, Liu Peter S, Franke Yvonne, Eigenbrot Charles, Forrest William F, Schwartz Lawrence B, Lazarus Robert A

Abstract excerpt

Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of the allergic inflammatory responses in asthma. During acute hypersensitivity reactions, mast cells degranulate, releasing active tetramer as a complex with proteoglycans. Extensive efforts have focused on developing therapeutic β-tryptase inhibitors, but its unique activation mechanism is less well-explored. Tryptase is...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29661938
DOI: 10.1074/jbc.M117.812016
PMCID: PMC6016454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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