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Article

The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration.

The Journal of biological chemistry - 16 Jul 1999

Sambrano G R, Coughlin S R

Abstract excerpt

The G protein-coupled thrombin receptor, protease-activated receptor 1 (PAR1), mediates many of the actions of thrombin on cells including chemotaxis. In contrast to the reversible agonist binding that regulates signaling by most G protein-coupled receptors (GPCRs), PAR1 is activated by an irreversible proteolytic mechanism. Although activated PAR1 is phosphorylated, uncoupled, and internalized like typical...

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Identifiers

PMID: 10400633
DOI: 10.1074/jbc.274.29.20178

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