Article

Activation of GPR116/ADGRF5 by its tethered agonist requires key amino acids in extracellular loop 2 of the transmembrane region

2021-04-02

Abstract excerpt

The mechanistic details of the tethered agonist mode of activation for adhesion GPCRs has not been completely deciphered. We set out to investigate the physiologic importance of autocatalytic cleavage upstream of the agonistic peptide sequence, an event necessary for NTF displacement and subsequent receptor activation. To examine this hypothesis, we characterized tethered agonist-mediated activation of GPR116 in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fff358a4-ca54-5592-b0a7-a5c05f49fbc9
DOI: 10.1101/2021.04.01.438115

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of GPR116/ADGRF5 by its tethered agonist requires key amino acids in extracellular loop 2 of the transmembrane regionDOI 10.1101/2021.04.01.438115Read

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist.Semantic proximity Read

Activation of Adhesion G Protein-coupled Receptors: AGONIST SPECIFICITY OF STACHEL SEQUENCE-DERIVED PEPTIDES.Semantic proximity Read

Adhesion-GPCRs: emerging roles for novel receptorsSemantic proximity Read

Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2.Semantic proximity Read

Pathophysiological impact of the adhesion G protein-coupled receptor familySemantic proximity Read

Structural basis for adhesion G protein-coupled receptor Gpr126 functionSemantic proximity Read

Dissociation of the intramolecularly cleaved N- and C-terminal fragments of the adhesion G protein-coupled receptor GPR133 (ADGRD1) increases canonical signalingSemantic proximity Read

Characterization and functional study of a cluster of four highly conserved orphan adhesion‐GPCR in mouseSemantic proximity Read

Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation.Semantic proximity Read

GPR56 interacts with extracellular matrix and regulates cancer progression.Semantic proximity Read

The clinical relevance of the adhesion G protein-coupled receptor F5 for human diseases and cancersSemantic proximity Read

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.Semantic proximity Read