Article
The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Denko N C, Giaccia A J, Stringer J R, Stambrook P J
Abstract excerpt
Many human tumors contain an activating mutation in one of the ras protooncogenes. Additionally, these tumor cells are often heteroploid and characterized by chromosome breaks and rearrangements that are consequences of the genomic instability that is thought to contribute to tumor progression. T...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Cell Cycle
- Chromosome Aberrations
- DNA Damage
- DNA Primers
- Fibroblasts
- Gene Expression
- Genes, p53
- Genes, ras
- Humans