Article
The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994
Denko N C, Giaccia A J, Stringer J R, Stambrook P J
Abstract excerpt
Many human tumors contain an activating mutation in one of the ras protooncogenes. Additionally, these tumor cells are often heteroploid and characterized by chromosome breaks and rearrangements that are consequences of the genomic instability that is thought to contribute to tumor progression. The concurrence of ras mutations and genomic instability in tumors prompted us to ask whether selective induction of an...
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