Article
A role for chromosomal instability in the development of and selection for radioresistant cell variants.
British journal of cancer - 1 Feb 2001
Limoli C L, Corcoran J J, Jordan R, Morgan W F, Schwartz J L
Abstract excerpt
Chromosome instability is a common occurrence in tumour cells. We examined the hypothesis that the elevated rate of mutation formation in unstable cells can lead to the development of clones of cells that are resistant to the cancer therapy. To test this hypothesis, we compared chromosome instability to radiation sensitivity in 30 independently isolated clones of GM10115 human-hamster hybrid cells. There was a...
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