Article
Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins.
Cancer research - 1 Jun 2002
El-Hizawi Sally, Lagowski James P, Kulesz-Martin Molly, Albor Amador
Abstract excerpt
Gene amplification accompanies tumor progression and is involved in the development of drug resistance. Previously, we reported (A. Albor et al., Cancer Res. 58: 2091-2094, 1998) that mutant p53 proteins conserve the capacity to interact with and activate topoisomerase I, and that this could be a mechanism for induction of genomic instability by mutant p53 proteins. To test this hypothesis, the effect of...
Topics
- Aspartic Acid
- Bone Neoplasms
- Camptothecin
- DNA Topoisomerases, Type I
- Enzyme Inhibitors
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Humans
- Mutation
- Osteosarcoma
- Phenotype
- Phosphonoacetic Acid
- Protein Structure, Tertiary
- Topoisomerase I Inhibitors
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53