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Article

Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins.

Cancer research - 1 Jun 2002

El-Hizawi Sally, Lagowski James P, Kulesz-Martin Molly, Albor Amador

Abstract excerpt

Gene amplification accompanies tumor progression and is involved in the development of drug resistance. Previously, we reported (A. Albor et al., Cancer Res. 58: 2091-2094, 1998) that mutant p53 proteins conserve the capacity to interact with and activate topoisomerase I, and that this could be a mechanism for induction of genomic instability by mutant p53 proteins. To test this hypothesis, the effect of...

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PMID: 12036943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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