Article
Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.
Somatic cell and molecular genetics - 1 Mar 1997
Wani M A, Denko N C, Stambrook P J
Abstract excerpt
Among the multiple genetic changes that occur during cancer progression are the activation of proto-oncogenes and the inactivation or loss of genes encoding tumor suppressors. The potential roles for these genes in the perturbation of genome stability continues to be of major interest. We have pr...
Topics
- 3T3 Cells
- Animals
- Blotting, Southern
- Cell Division
- Cell Line, Transformed
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- GTP-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, ras
- In Situ Hybridization, Fluorescence
- Methotrexate
- Mice
- Phenotype
- Transformation, Genetic
- Transgenes
- rap GTP-Binding Proteins