Article
Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT.
Genes, chromosomes & cancer - 1 Aug 1997
Boukamp P, Popp S, Altmeyer S, Hülsen A, Fasching C, Cremer T, Fusenig N E
Abstract excerpt
Altered growth and differentiation and a highly abnormal karyotype are generally believed to be indicators for tumorigenic conversion of human cells. Inactivation of TP53 is supposedly one possible mechanism for accelerated genetic aberrations via reduced control of the genetic integrity. To exam...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Chromosome Banding
- Flow Cytometry
- Genes, p53
- Humans
- In Situ Hybridization, Fluorescence
- Karyotyping
- Keratinocytes
- Metaphase
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Phenotype
- Skin Neoplasms