The role of recombinational hotspots in genome instability in mammalian cells.

doi:10.1002/bies.950121204

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Article

The role of recombinational hotspots in genome instability in mammalian cells.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Dec 1990

Murnane J P

Abstract excerpt

Genome instability has been associated with progression of transformed cells to high tumorigenicity. Although genome instability may result from a variety of factors, some studies suggest that DNA in the region of a chromosome rearrangement can subsequently have much higher rates of DNA deletions...

Topics

Animals
Cell Transformation, Neoplastic
DNA
DNA, Viral
Gene Amplification
Gene Rearrangement
Mammals
Mutation
Plasmids
Recombination, Genetic
Repetitive Sequences, Nucleic Acid
Transfection

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