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Article

Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer.

Oncogene - 28 Jun 2007

Kohonen-Corish M R J, Sigglekow N D, Susanto J, Chapuis P H, Bokey E L, Dent O F, Chan C, Lin B P C, Seng T J, Laird P W, Young J, Leggett B A, Jass J R, Sutherland R L

Abstract excerpt

The mutated in colorectal cancer (MCC) gene is in close linkage with the adenomatous polyposis coli (APC) gene on chromosome 5, in a region of frequent loss of heterozygosity in colorectal cancer. The role of MCC in carcinogenesis, however, has not been extensively analysed, and functional studies are emerging, which implicate it as a candidate tumor suppressor gene. The aim of this study was to examine loss of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17260021
DOI: 10.1038/sj.onc.1210210

Genes

MCC
APC
BRAF
CDKN2A
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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