Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.

doi:10.1093/hmg/3.3.443

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Article

Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.

Human molecular genetics - 1 Mar 1994

Curtis L J, Bubb V J, Gledhill S, Morris R G, Bird C C, Wyllie A H

Abstract excerpt

The adenomatous polyposis coli (APC) gene, which transmits familial adenomatous polyposis, is frequently mutated in sporadic colorectal tumours. Acquired somatic mutations have also been reported in a second gene, mutated in colorectal cancer (MCC), which lies within 500 kb of APC on chromosome 5...

Topics

Alleles
Base Sequence
Colorectal Neoplasms
DNA
Gene Deletion
Heterozygote
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

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