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Article

Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.

Human molecular genetics - 1 Mar 1994

Curtis L J, Bubb V J, Gledhill S, Morris R G, Bird C C, Wyllie A H

Abstract excerpt

The adenomatous polyposis coli (APC) gene, which transmits familial adenomatous polyposis, is frequently mutated in sporadic colorectal tumours. Acquired somatic mutations have also been reported in a second gene, mutated in colorectal cancer (MCC), which lies within 500 kb of APC on chromosome 5q21 and has thus been implicated in tumour development. Further evidence for an oncosuppressor gene other than APC on...

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Source

Identifiers

PMID: 8012355
DOI: 10.1093/hmg/3.3.443

Genes

MCC
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.PMID 8012355Read ↗

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.Semantic proximity Read ↗

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Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene.Semantic proximity Read ↗

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.Semantic proximity Read ↗

Chromosome 5 allele loss in human colorectal carcinomas.Semantic proximity Read ↗

Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation.Semantic proximity Read ↗

Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

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