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Article

K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis.

Cancer - 1 Jun 1994

Imai M, Hoshi T, Ogawa K

Abstract excerpt

BACKGROUND: Although the prevalence of K-ras codon 12 mutations in biliary tract (BT) tumors has been addressed in previous studies, the results have shown large discrepancies in mutation frequency. METHODS: K-ras codon 12 mutations were investigated by polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE), a sensitive method for detecting DNA base changes, in a large series of BT tumors....

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PMID: 8194013
DOI: 10.1002/1097-0142(19940601)73:11<2727::aid-cncr2820731113>3.0.co;2-#

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