Article
[Frequency of K-ras mutation in biliary and pancreatic tumors].
Revista medica de Chile - 1 Dec 2005
Roa Juan Carlos, Anabalón Leonardo, Tapia Oscar, Melo Angélica, de Aretxabala Xabier, Roa Iván
Abstract excerpt
BACKGROUND: The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas. AIM: To determine the frequency of K-ras gene codon 12 mutation in pancreatic and biliary tumors. MATERIAL AND METHODS: Samples of 35 gallbladder, 15 ampulla of Vater, 10 biliary tract and 9 pancreatic tumors, were analyzed. The tumor tissue was...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
- Codon
- Female
- Gallbladder Neoplasms
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Pancreatic Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Sex Factors
- Survival Analysis