Article
Diagnostic utility of K-ras mutational analysis on bile obtained by endoscopic retrograde cholangiopancreatography.
Gastrointestinal endoscopy - 1 Oct 1995
Lee J G, Leung J W, Cotton P B, Layfield L J, Mannon P J
Abstract excerpt
BACKGROUND: Because K-ras oncogene mutations are present in more than 90% of pancreaticobiliary tumors, we tested prospectively whether K-ras mutational analysis of bile samples obtained during ERCP was superior to conventional bile cytology for diagnosis of malignancy. METHODS: Bile samples from 20 patients undergoing ERCP for evaluation of jaundice were examined by both cytologic study and the polymerase chain...
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