Article
Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer.
Anticancer research - 1 Jan 2000
Abbruzzese J L, Evans D B, Raijman I, Larry L, King T, Leach S D, Frazier M L
Abstract excerpt
BACKGROUND: Because treatment of advanced pancreatic cancer is often unsuccessful, early detection is important. Codon 12 c-Ki-ras mutations have been found in 80-90% of pancreatic cancer cases and are a potential early marker for pancreatic cancer, but obtaining tissue or fluid for analysis can be difficult. We therefore evaluated whether mutant c-Ki-ras could be detected in bile samples obtained from pancreatic...
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