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Article

High rate of mutation reporter gene inactivation during human T cell proliferation.

Immunogenetics - 1 Feb 2007

Gabdoulkhakova Aida, Henriksson Gunnel, Avkhacheva Nadezhda, Sofin Alexander, Bredberg Anders

Abstract excerpt

Caspase activation and degradation of deoxyribonucleic acid (DNA) damage response factors occur during in vitro T-cell proliferation, and an increased frequency of hypoxanthine-guanine phosphoribosyltransferase (HPRT)-negative variants have been reported in conditions associated with in vivo T-cell proliferation. We have applied two human somatic cell mutation reporter assays, for the HPRT and...

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PMID: 17180623
DOI: 10.1007/s00251-006-0180-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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