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Article

Characteristics of HPRT-mutant T cell lines in a lupus patient treated with cyclophosphamide.

Arthritis and rheumatism - 1 Oct 1994

Wood G M, Dawisha S, Gourley M

Abstract excerpt

This report describes T cell lines derived from a patient with subacute cutaneous lupus after treatment with intravenous pulse cyclophosphamide. We selected for mitotically active, hypoxanthine-guanine phosphoribosyltransferase-deficient (HPRT-) T cells, by culture in a selective medium containing 6-thioguanine. When HPRT- cell lines were derived 6 days after pulse cyclophosphamide (CYC) treatment, they were...

Topics

Adult
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Line
Cyclophosphamide
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Infusions, Intravenous
Lupus Erythematosus, Systemic
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 7945481
DOI: 10.1002/art.1780371021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7945481-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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