Article
Gene targeting in human somatic cells. Complete inactivation of an interferon-inducible gene.
European journal of biochemistry - 1 Dec 1993
Porter A C, Itzhaki J E
Abstract excerpt
The role, if any, of the human interferon-inducible 6-16 gene in the establishment of a cellular antiviral state is unknown. To address this problem, and as part of a wider investigation of homologous recombination (HR) and its applications in somatic cells, we have been using HR to disrupt the 6-16 gene in human cell lines [Itzhaki, J. E. & Porter, A. C. G. (1991) Nucleic Acids Res. 19, 3835-3842.] We describe...
Topics
- Base Sequence
- DNA Primers
- Gene Expression Regulation
- Genetic Predisposition to Disease
- HeLa Cells
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Interferons
- Molecular Sequence Data
- Mutation
- Phenotype