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Article

Expression of human PKR protein kinase in transgenic mice.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2002

Ladiges Warren, Morton John, Hopkins Heather, Wilson Ruth, Filley Gina, Ware Carol, Gale Michael

Abstract excerpt

There is a large amount of evidence describing the expression, interaction, and mode of activation of the human interferon (IFN)-mediated double-stranded RNA-activated protein kinase (PKR) gene. Studies from Pkr-null mice have defined the kinase as a transducer of dsRNA signals that converge on transcription, translation, and apoptotic programs involved in the innate resistance to viral infection. In vitro...

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PMID: 12034040
DOI: 10.1089/107999002753675758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Expression of human PKR protein kinase in transgenic mice.PMID 12034040Read ↗

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