Analysis of p53 gene mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma.

doi:10.1016/0304-3835(94)90064-7

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Article

Analysis of p53 gene mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma.

Cancer letters - 29 Apr 1994

Konishi K, Yamanishi K, Ishizaki K, Yamada K, Kishimoto S, Yasuno H

Abstract excerpt

To determine the role of the p53 gene in the pathogenesis of basal cell carcinoma (BCC), we screened mutations of the gene in 11 cases of BCCs using the polymerase chain reaction (PCR) and single-stranded conformation polymorphism (SSCP). However, in all the coding exons of the gene analysed, no evidence suggesting the mutations were obtained. On the other hand, in 2 of 5 informative cases of our BCCs (40%) we...

Topics

Aged
Aged, 80 and over
Alleles
Carcinoma, Basal Cell
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 9
Exons
Female
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8187055
DOI: 10.1016/0304-3835(94)90064-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8187055-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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