Article
p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.
Cancer research - 15 Feb 1997
D'Errico M, Calcagnile A S, Corona R, Fucci M, Annessi G, Baliva G, Tosti M E, Pasquini P, Dogliotti E
Abstract excerpt
Tumor DNA from 45 primary basal cell carcinoma (BCC) biopsies was screened for p53 gene mutations, chromosome 9 allele loss, and microsatellite instability. p53 mutation frequency increased significantly as a function of the age at BCC onset ranging from 6% (1/16) in early BCC (before age 40 years) to 35% (10/29) in late BCC. All p53 mutations found implicated sunlight as the mutagen. Chromosome 9 instability...
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