Article
p53 mutations and chromosome instability in basal cell carcinomas developed at an early or late age.
Cancer research - 15 Feb 1997
D'Errico M, Calcagnile A S, Corona R, Fucci M, Annessi G, Baliva G, Tosti M E, Pasquini P, Dogliotti E
Abstract excerpt
Tumor DNA from 45 primary basal cell carcinoma (BCC) biopsies was screened for p53 gene mutations, chromosome 9 allele loss, and microsatellite instability. p53 mutation frequency increased significantly as a function of the age at BCC onset ranging from 6% (1/16) in early BCC (before age 40 year...
Topics
- Adult
- Age Distribution
- Age of Onset
- Aged
- Aged, 80 and over
- Carcinoma, Basal Cell
- Chromosome Aberrations
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Microsatellite Repeats
- Middle Aged
- Mutation
- Skin Neoplasms