Article
Molecular genetic analysis excludes implantation metastasis of basal cell carcinomas.
Archives of pathology & laboratory medicine - 1 Sept 2003
Hafner Christian, Hartmann Arndt, Knuechel Ruth, Dietmaier Wolfgang, Landthaler Michael, Vogt Thomas
Abstract excerpt
Basal cell carcinoma (BCC) of the skin is the most common tumor in the white population. A 66-year-old man developed 2 BCCs at the left parietal region of the head and at the helix of the left ear. The 2 lesions matched exactly when pressing the ear against the head, suggesting an implantation metastasis mechanism. Molecular genetic techniques were used to confirm or exclude such a mechanism in this rare clinical...
Topics
- Aged
- Carcinoma, Basal Cell
- DNA Mutational Analysis
- DNA, Neoplasm
- Diagnosis, Differential
- Ear
- Head
- Humans
- Loss of Heterozygosity
- Male
- Mutation
- Neoplasm Seeding
- Neoplasms, Second Primary
- Polymerase Chain Reaction
- Skin Neoplasms
- Tumor Suppressor Protein p53