Article
High frequency of loss of heterozygosity on chromosome region 9p21-p22 but lack of p16INK4a/p19ARF mutations in greek patients with basal cell carcinoma of the skin.
The Journal of investigative dermatology - 1 Oct 2000
Saridaki Z, Koumantaki E, Liloglou T, Sourvinos G, Papadopoulos O, Zoras O, Spandidos D A
Abstract excerpt
Basal cell carcinoma of the skin is the most common neoplasia in humans. Previous studies have shown the existence of allelic imbalance (loss of heterozygosity and microsatellite instability) in BCC on several human chromosomes. Chromosome region 9p21-p22 harbors the CDKN2a/p16INK4a, p19ARF, and p15INK4b tumor suppressor genes. To determine the contribution of these genes to the development of basal cell...
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