Article
An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype.
Biochemical pharmacology - 20 Apr 1994
Barham H M, Lennard M S, Tucker G T
Abstract excerpt
The female dark agouti (DA) rat lacks CYP2D1, the equivalent enzyme in the rat to human CYP2D6 (debrisoquine hydroxylase), and shows impaired metabolism of a number of CYP2D6 substrates. However, from the data available in the literature it is not entirely clear whether the enzyme deficiency in t...
Topics
- Animals
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Isoenzymes
- Kinetics
- Metoprolol
- Microsomes, Liver
- Mixed Function Oxygenases
- Phenotype
- Quinidine
- Quinine
- Rats
- Rats, Wistar
- Substrate Specificity