Article
Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Guttendorf R J, Kostenbauder H B, Wedlund P J
Abstract excerpt
Although genetic constitution is recognized as an important factor in drug elimination, there is still only a modest amount of information about its impact on stereoselective drug disposition. To examine how strain differences in cytochrome P-450 expression may affect stereoselective drug elimination, the disposition of R- and S-propranolol was examined in female Sprague-Dawley (SD) and Dark Agouti (DA) rats. The...
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