Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats.

Article

Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Guttendorf R J, Kostenbauder H B, Wedlund P J

Abstract excerpt

Although genetic constitution is recognized as an important factor in drug elimination, there is still only a modest amount of information about its impact on stereoselective drug disposition. To examine how strain differences in cytochrome P-450 expression may affect stereoselective drug elimina...

Topics

Animals
Blood Proteins
Debrisoquin
Female
Half-Life
Phenotype
Propranolol
Protein Binding
Rats
Rats, Inbred Strains
Stereoisomerism
Tissue Distribution

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