Article
The role of cytochrome P450 in developmental pharmacology.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine - 1 Dec 1994
Rogers A S
Abstract excerpt
Numerous sources of human heterogeneity affect biotransformation of compounds. Cytochrome P450, the primary oxidative pathway of drug metabolism, is the dominant phase I oxidative system metabolizing, to some degree, most of the drugs used clinically in humans. The P450 pathway is a major site of drug-drug, drug-diet, and drug-disease/condition interactions. Functional variability in this system can have...
Topics
- Adolescent
- Adult
- Biotransformation
- Child
- Child, Preschool
- Cytochrome P-450 Enzyme System
- Drug Interactions
- Female
- Genotype
- Humans
- Infant
- Infant, Newborn