Article
CYP2D1 polymorphism in methamphetamine-treated rats: genetic differences in neonatal mortality and effects on spatial learning and acoustic startle.
Neurotoxicology and teratology - 1 Jan 2000
Vorhees C V, Reed T M, Schilling M A, Fisher J E, Moran M S, Cappon G D, Nebert D W
Abstract excerpt
d-Methamphetamine (MA) is one of more than two dozen drugs included in the cytochrome P450-mediated "debrisoquine oxidation polymorphism" panel. The human gene (CYP2D6) is responsible for the "poor metabolizer" (PM) and "extensive metabolizer" (EM) phenotypes for drugs such as MA; a similar polym...
Topics
- Acoustic Stimulation
- Alcohol Oxidoreductases
- Animals
- Animals, Newborn
- Animals, Suckling
- Aryl Hydrocarbon Hydroxylases
- Body Weight
- Cytochrome P-450 Enzyme System
- Cytochrome P450 Family 2
- Drug Evaluation, Preclinical
- Female
- Maze Learning
- Methamphetamine
- Phenotype