Article
Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population.
Clinical pharmacology and therapeutics - 1 May 1994
May D G, Porter J, Wilkinson G R, Branch R A
Abstract excerpt
Phenotypic trait values in 166 healthy white subjects (age range, 18 to 88 years) were determined for dapsone N-hydroxylation, dapsone N-acetylation, debrisoquin 4-hydroxylation, and S-mephenytoin 4'-hydroxylation after single oral dose administration of the probe drugs dapsone (100 mg), debrisoq...
Topics
- Acetylation
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Dapsone
- Debrisoquin
- Female
- Humans
- Hydroxylation
- Male
- Mephenytoin
- Middle Aged
- Mixed Function Oxygenases
- Phenotype