Article
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2.
Pharmacogenetics - 1 Feb 1998
Yamamoto Y, Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalez F J, Fujita S
Abstract excerpt
The Dark Agouti rat has been proposed as a model for the human debrisoquine 4-hydroxylase polymorphism. Earlier studies suggested that the poor metabolizer phenotype in the Dark Agouti rat is caused by the absence of the expression of CYP2D1 mRNA. Although CYP2D1 is the major enzyme catalyzing de...
Topics
- Adrenergic beta-Antagonists
- Animals
- Baculoviridae
- Cell Line
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Gene Expression
- Humans
- Male
- Phenotype
- Polymorphism, Genetic
- Propanolamines
- RNA, Messenger
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins
- Spodoptera