Article
Interstrain comparison of hepatic and renal microsomal carcinogen metabolism and liver S9-mediated mutagenicity in DA and Lewis rats phenotyped as poor and extensive metabolizers of debrisoquine.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Hietanen E, Malaveille C, Camus A M, Béréziat J C, Brun G, Castegnaro M, Michelon J, Idle J R, Bartsch H
Abstract excerpt
Lewis (extensive metabolizers) and DA (poor metabolizers) rat strains show genetic polymorphism for the gene regulating debrisoquine 4-hydroxylation in a manner analogous to human drug polymorphism and show also a different toxicological response to aflatoxin B1. In order to investigate the under...
Topics
- 2-Acetylaminofluorene
- Aflatoxin B1
- Aflatoxins
- Animals
- Benzopyrenes
- Biotransformation
- Carcinogens
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dihydroxydihydrobenzopyrenes
- Female
- Glucuronosyltransferase
- Hydroxylation