Article
Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes.
Biochemical pharmacology - 24 Feb 1993
Kerry N L, Somogyi A A, Mikus G, Bochner F
Abstract excerpt
The O-demethylation of dextromethorphan (DM) to dextrorphan (DR) is catalysed by the polymorphic CYP2D6 (cytochrome P4502D6) isozyme in man. DM is commonly used as a probe for phenotyping subjects as either poor or extensive metabolizers for the debrisoquine/sparteine oxidative polymorphism via C...
Topics
- Animals
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Female
- Isoenzymes
- Kinetics
- Methylation
- Microsomes, Liver
- Oxidation-Reduction
- Phenotype
- Rats
- Rats, Sprague-Dawley