Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals.

IARC scientific publications - 1 Jan 1991

Wolf C R

Abstract excerpt

The susceptibility of a tissue to the toxic and/or carcinogenic effects of chemicals is determined by a variety of factors, which include their rate of metabolic activation by the cytochrome P450-dependent monooxygenases. Individual differences in the levels of cytochrome P450 expression would be expected, and are known, to give rise to profound differences in toxicological response. Such effects are almost best...

Topics

Animals
Balkan Nephropathy
Base Sequence
Biotransformation
Carcinogens
Cardiovascular Agents
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
DNA Mutational Analysis
Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dogs

Enzyme Induction

Female

Genes

Genetic Predisposition to Disease

Humans

Inactivation, Metabolic

Source

Open in PubMed

Identifiers

PMID: 1820342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1820342-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals.PMID 1820342Read ↗

Genetic variability in susceptibility and response to toxicants.Semantic proximity Read ↗

Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity.Semantic proximity Read ↗

Sex- and strain-specific expression of cytochrome P450s in Ochratoxin A-induced genotoxicity and carcinogenicity in ratsSemantic proximity Read ↗

[Factors contributing to interindividual variability to chemical toxicity].Semantic proximity Read ↗

Ethnic and genetic differences in metabolism genes and risk of toxicity and cancer.Semantic proximity Read ↗

Metabolism of xenobiotics and chemical carcinogenesis.Semantic proximity Read ↗

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.Semantic proximity Read ↗

Genetic variability in susceptibility and response to toxicants.Semantic proximity Read ↗

Polymorphism of drug-metabolizing enzymes in relation to individual susceptibility to industrial chemicals.Semantic proximity Read ↗

The relevance of xenobiotic metabolism in the interindividual susceptibility to chemicals.Semantic proximity Read ↗

Study design and genetic susceptibility factors in the risk assessment of chemical carcinogens.Semantic proximity Read ↗

The role of cytochrome P450 in developmental pharmacology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.