Article
Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling.
Nature - 26 May 1994
Nakamura Y, Russell S M, Mess S A, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard W J
Abstract excerpt
The interaction of interleukin-2 (IL-2) and IL-2 receptors critically regulates the T-cell immune response following antigen activation. IL-2 can signal through high or intermediate affinity receptors which contain IL-2R alpha (refs 3, 4) +beta (refs 5-8) +gamma (ref. 9) or beta+gamma chains, res...
Topics
- Animals
- Antibodies, Bispecific
- Antibodies, Monoclonal
- Biopolymers
- Cell Division
- Cell Line
- Cytoplasm
- Humans
- Mice
- Mutation
- Receptors, Interleukin-2
- Recombinant Fusion Proteins
- Signal Transduction
- Structure-Activity Relationship