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Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way.

Blood - 1 Feb 1994

Voss S D, Hong R, Sondel P M

Abstract excerpt

The recent discovery of molecular defects in three forms of X-linked immunodeficiency has quickly transformed the study of immunodeficiency into one of the most exciting in basic and clinical immunology. The identification of defects in the IL-2R gamma chain in the etiology of X-linked SCID has suggested a heretofore unanticipated functional role of the gamma chain in immunologic development. While new and novel...

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PMID: 8298124

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ADA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way.PMID 8298124Read ↗

The molecular basis of X-linked severe combined immunodeficiency: the role of the interleukin-2 receptor gamma chain as a common gamma chain, gamma c.Semantic proximity Read ↗

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Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.Semantic proximity Read ↗

X-linked severe combined immunodeficiency: from molecular cause to gene therapy within seven years.Semantic proximity Read ↗

IL2RG-related immunodeficiencies: from SCID to atypical presentations.Semantic proximity Read ↗

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.Semantic proximity Read ↗

The γc family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune responseSemantic proximity Read ↗

Signaling from the IL-2 receptor to the nucleus.Semantic proximity Read ↗

Patients with T⁺/low NK⁺ IL-2 receptor γ chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency.Semantic proximity Read ↗

Immune deficiencies due to defects in cytokine signaling.Semantic proximity Read ↗

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157. 1993.Semantic proximity Read ↗

An interleukin-2 receptor gamma chain mutation with normal thymus morphology.Semantic proximity Read ↗

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