Article
Severe combined immunodeficiency, interleukin-2 (IL-2), and the IL-2 receptor: experiments of nature continue to point the way.
Blood - 1 Feb 1994
Voss S D, Hong R, Sondel P M
Abstract excerpt
The recent discovery of molecular defects in three forms of X-linked immunodeficiency has quickly transformed the study of immunodeficiency into one of the most exciting in basic and clinical immunology. The identification of defects in the IL-2R gamma chain in the etiology of X-linked SCID has s...
Topics
- Humans
- Interleukin-2
- Leukemia
- Mutation
- Receptors, Interleukin-2
- Severe Combined Immunodeficiency
- Structure-Activity Relationship
- T-Lymphocytes
- X Chromosome