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Article

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Immunity - 19 May 2015

Mitra Suman, Ring Aaron M, Amarnath Shoba, Spangler Jamie B, Li Peng, Ju Wei, Fischer Suzanne, Oh Jangsuk, Spolski Rosanne, Weiskopf Kipp, Kohrt Holbrook, Foley Jason E, Rajagopalan Sumati, Long Eric O, Fowler Daniel H, Waldmann Thomas A, Garcia K Christopher, Leonard Warren J

Abstract excerpt

Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. IL-2 is of considerable therapeutic interest, but harnessing its actions in a controllable manner remains a challenge. Previously, we have engineered an IL-2 "superkine" with enhanced affinity for IL-2Rβ. Here, we describe next-generation IL-2 variants that function as "receptor...

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Source

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Identifiers

PMID: 25992859
DOI: 10.1016/j.immuni.2015.04.018
PMCID: PMC4560365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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