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Article

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology.

Clinical immunology (Orlando, Fla.) - 1 Sept 2024

Sommer Charline, Jacob Sophie, Bargmann Tonia, Shoaib Muhammad, Alshaikhdeeb Basel, Satagopam Venkata P, Dehmel Susann, Neuhaus Vanessa, Braun Armin, Sewald Katherina

Abstract excerpt

Interleukin-2 (IL-2) holds promise for the treatment of cancer and autoimmune diseases, but its high-dose usage is associated with systemic immunotoxicity. Differential IL-2 receptor (IL-2R) regulation might impact function of cells upon IL-2 stimulation, possibly inducing cellular changes similar to patients with hypomorphic IL2RB mutations, presenting with multiorgan autoimmunity. Here, we show that sustained...

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Identifiers

PMID: 38950723
DOI: 10.1016/j.clim.2024.110288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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