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Article

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Nature - 25 Mar 2012

Levin Aron M, Bates Darren L, Ring Aaron M, Krieg Carsten, Lin Jack T, Su Leon, Moraga Ignacio, Raeber Miro E, Bowman Gregory R, Novick Paul, Pande Vijay S, Fathman C Garrison, Boyman Onur, Garcia K Christopher

Abstract excerpt

The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of leukocytes, including T cells and natural killer (NK) cells. Considerable effort has been invested in using IL-2 as a therapeutic agent for a variety of immune disorders ranging from AIDS to cancer. However, adverse effects have limited its use in the clinic. On activated T cells, IL-2 signals through a quaternary 'high...

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Identifiers

PMID: 22446627
DOI: 10.1038/nature10975
PMCID: PMC3338870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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