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Article

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1993

Cao X, Kozak C A, Liu Y J, Noguchi M, O'Connell E, Leonard W J

Abstract excerpt

The IL-2R gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2Rs, playing critical roles for ligand binding and internalization. Recently, our laboratory has demonstrated that IL-2R gamma mutation results in X chromosome-linked severe combined immunodeficiency in humans, suggesting that IL-2R gamma plays a vital role in thymic maturation of human T cells. We now report the...

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Identifiers

PMID: 8378320
DOI: 10.1073/pnas.90.18.8464
PMCID: PMC47377

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