Article
Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1993
Cao X, Kozak C A, Liu Y J, Noguchi M, O'Connell E, Leonard W J
Abstract excerpt
The IL-2R gamma chain (IL-2R gamma) is an essential component of high- and intermediate-affinity IL-2Rs, playing critical roles for ligand binding and internalization. Recently, our laboratory has demonstrated that IL-2R gamma mutation results in X chromosome-linked severe combined immunodeficien...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Chromosome Mapping
- Conserved Sequence
- Crosses, Genetic
- DNA
- Female
- Gene Library
- Humans
- Lymphocytes
- Macromolecular Substances
- Male