Article
Signaling from the IL-2 receptor to the nucleus.
Cytokine & growth factor reviews - 1 Dec 1997
Lin J X, Leonard W J
Abstract excerpt
Interleukin-2 has pleiotropic actions on the immune system and plays a vital role in the modulation of immune responses. Our current understanding of IL-2 signaling has resulted from in vitro studies that have identified the signaling pathways activated by IL-2, including the Jak-STAT pathways, and from in vivo studies that have analyzed mice in which IL-2, each chain of the receptor, as well a number of...
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